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Organic Solvent

P-Toluene Sulfony Chloride(PTSC), C7H7ClO2S

CHEMICAL NAME: P-Toluene Sulfony Chloride  CHEMICAL FORMULA: C7H7ClO2S   PROPERTY: White crystalline USE: Intermediates in the synthesis of drugs, dyestuff and auxiliaries. PACKING: 25kg pla
Product Details

CHEMICAL NAME: P-Toluene Sulfony Chloride (PTSC)

CHEMICAL FORMULA: C7H7ClO2S

 

PROPERTY: P-Toluene Sulfony Chloride  White crystalline

USE: Intermediates in the synthesis of drugs, dyestuff and auxiliaries.

PACKING: 25kg plastic woven bag, or 50kg fiber drum.

SPECIFICATION

 

Item Index
Assay ≥ 99.0%
Moisture ≤ 0.1%
Free acid ≤ 0.1%
o-Toluene Sulfonyl Chloride ≤ 0.1%
Color(APHA) ≤ 20

(sulfonyl transfer reagent; O-sulfonylation of alcohols for conversion to chlorides or intermolecular and intramolecular displacements, vicinal diols for epoxidation, 1,3-diols for oxetane formation, carboxylic acids for esterification or decarboxylation, oximes for Beckmann rearrangements or fragmentations and Neber rearrangements, hydroxamic acids for Lossen rearrangements, nitrones for rearrangements, conversion of N-cyclopropylhydroxylamines to β-lactams; N-sulfonylation of aliphatic amines for subsequent deamination or displacement, aromatic amines for protection; C-sulfonylation of alkenes and silylalkynes; dehydration of ureas, formamides, and amides)

Alternate Names: tosyl chloride.

Physical Data: mp 67–69 °C; bp 146 °C/15 mmHg.

Solubility: insol H2O; freely sol ethanol, benzene, chloroform, ether.

Form Supplied in: white solid, widely available.

Purification: upon prolonged standing the material develops impurities of p-toluenesulfonic acid and HCl. Tosyl chloride is purified by dissolving 10 g in a minimum volume of CHCl3 (ca. 25 mL), filtering, and diluting with five volumes (ca. 125 mL) of petroleum ether (bp 30–60 °C) to precipitate impurities (mostly tosic acid, mp 101–104 °C). The solution is filtered, clarified with charcoal, and concentrated to ca. 40 mL by evaporation. Further evaporation to a very small volume gives 7 g of pure white crystals (mp 67.5–68.5 °C).

Tosyl chloride may also be recrystallized from petroleum ether, from benzene, or from toluene/petroleum ether (bp 40–60 °C) in the cold. Tosyl chloride in diethyl ether can be washed with aqueous 10% NaOH until colorless, then dried with Na2SO4 and crystallized by cooling in powdered dry ice. It can also be purified by dissolving in benzene, washing with aqueous 5% NaOH, drying with K2CO3 or MgSO4, and distilling under reduced pressure.

Handling, Storage, and Precautions: freshly purified tosyl chloride should be used for best results. Tosyl chloride is a moisture-sensitive, corrosive lachrymator.

 

* We will send you the product you ordered from the nearest warehouse. If one of the warehouses is out of stock, we will ship from another warehouse to reduce delivery time.
* If there are special circumstances, delivery is postponed. Inconvenience, please understand.
* If you need to inquire, please contact our sales manager E-mail: Sales@Ruistars.com
* Ruistars will regularly review the storage conditions to optimize them, please follow the online catalog, please pay attention.

 

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